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What To Do With Unused Embryos

By Annabelle Holman


In vitro fertilization is a procedure that childless couples may use when they are having trouble conceiving the natural way. It is the next step after artificial insemination has failed to yield the desired result. The IVF procedure involves fertilization of the woman's eggs in a petri dish and then implanting the resulting embryos. Unused embryos are a byproduct of this process. There are a number of different ways of dealing with these and it is the responsibility of the parents to determine what happens to them.

Once the eggs are fertilized, spare embryos that are not implanted may be frozen and stored. With modern vitrification freezing techniques, these living embryos may remain viable for years. Parents may decide to store them for future use, donate them for pioneering stem cell research, donate them to other couples who are unable to create their own embryos, continue to store them year after year or they may choose to have them destroyed.

Stem cells are very primitive cells that have the potential to differentiate into just about any other cell type in the human body. This property is referred to as pluripotency. These cells are becoming more and more useful in medicine. There is a significant potential for abuse of these cells. For this reason, their use is very closely regulated by governmental authorities.

Researchers at the University of Utah pioneered the procedure whereby a patient's own stem cells are injected into their left ventricle in an attempt to treat heart failure. At this point, they are called cardiac repair cells. They are derived from the patient's bone marrow and then cultured for just under fortnight, after which they are implanted into the heart. It turns out these cells are much hardier than the original cells that were harvested from the bone marrow.

The very first stem cells to be isolated came from mice in 1981. They were consequently harvested from humans in 1998. There are other sources of this material other than human embryos. For one thing, they may come from the bone marrow. They may also be isolated from peripheral blood or from neonatal umbilical cords.

Bone marrow comes from rich deposits deep inside the larger bones of the human body, most notably the pelvic bone. This process is very painful so it is performed under a general anesthetic. A wide-bore needle is injected into the hip and then into the bone marrow from which the tissue is collected.

Peripheral blood is not normally a rich source of stem cells. However, when donors are given hormones called growth factors a few days before the harvest increases their cell numbers. This process can take several hours. The blood of newborn babies is rich in stem cells. Those left in the umbilical cord are harvested and frozen for future transplantation. So far, umbilical cord cell transplants have only been conducted in children and small adults.

When couples who have stored embryos no longer want to have children, they may donate the spare embryos to scientific research or they may give them to other couples who are having trouble conceiving by other means.




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